A mysterious and vengeful spirit marks and pursues anybody who dares enter the house in which it resides.

While driving, the pregnant horror-movie actress Kyôko Harase and her fiancé are in a car crash. Kyôko loses her baby and her fiancé winds up in a coma. Kyôko was cursed together with a television crew when they shot a show in the haunted house where Kayako was brutally murdered by her husband years ago. While each member of the team dies or disappears, Kyôko is informed that she has a three-and-a-half-month-old fetus in her womb.

An American nurse living and working in Tokyo is exposed to a mysterious supernatural curse, one that locks a person in a powerful rage before claiming their life and spreading to another victim.

In Tokyo, a young woman (Tamblyn) is exposed to the same mysterious curse that afflicted her sister (Gellar). The supernatural force, which fills a person with rage before spreading to its next victim, brings together a group of previously unrelated people who attempt to unlock its secret to save their lives.